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  해당 관련 논문목록과 초록보기 링크 제공

  Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study Sci Rep 2024;14(1):854	초록보기
  Generation of a lethal mouse model expressing human ACE2 and TMPRSS2 for SARS-CoV-2 infection and pathogenesis Exp Mol Med 2024;56(5):1221-1229	초록보기
  The association between antibody responses and prolonged viable SARS-CoV-2 shedding in immunocompromised patients: a prospective cohort study J Infect Dis 2024;229(6):1722-1727	초록보기
  Characterization of high-affinity antibodies against the surface Gc protein of Dabie bandavirus / severe fever with thrombocytopenia syndrome virus Biochem Biophys Rep 2024;39	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Rise in Broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic Sci Adv 2023;10(9):eadk6425	초록보기
  A heterologous AZD1222 priming and BNT162b2 boosting regimen more efficiently elicits neutralizing antibodies, but not memory T cells, than the homologous BNT162b2 regimen Vaccine 2023;41(10):1694-1702	초록보기
  Function of the Speech Recognition of the Smartphone to Automatically Operate a Portable Sample Pretreatment Microfluidic System ACS SENSORS 2023;8(2):515-521	초록보기
  Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV Scientific Reports 2023;13:8189	초록보기
  Immunogenicity Differences of the ChAdOx1 nCoV-19 Vaccine According to Pre-Existing Adenovirus Immunity Vaccines 2023;11(4):784	초록보기
  Molecular evolution and targeted recombination of SARS-CoV-2 in South Korea iScience 2023;26(9):107689	초록보기
  Risk factors of pneumothorax and pneumomediastinum in COVID‑19: a matched case–control study BMC Infect Dis 2023;23(1):137	초록보기
  Triple immune modulator therapy for aberrant hyperinflammatory responses in severe COVID-19 Clin immunol 2023;251:109628	초록보기
  A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19 Korean J Intern Med 2023;38:101-112	초록보기
  An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi mBio 2023;14(1):e0154322	초록보기
  Clinical Utility of Sero-Immunological Responses Against SARS-CoV-2 Nucleocapsid Protein During Subsequent Prevalence of Wild-Type, Delta Variant, and Omicron Variant J Korean Med Sci 2023;38(37):e292	초록보기
  Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques J Med Virol 2023;95:e28847	초록보기
  Cytokine and chemokine profiles in acute severe fever with thrombocytopenia syndrome and scrub typhus in South Korea Am J Trop Med Hyg 2023;109(6):1311-1318	초록보기
  Experimental Infection and Transmission of SARS-CoV-2 Delta and Omicron Variants among Beagle Dogs Emerg Infect Dis 2023;29(4):782-785	초록보기
  Increased type III interferons and NK cell functions in SARS-CoV-2-infected children Signal Transduction and Targeted Therapy 2023;8(1):54	초록보기
  Risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA environmental contamination in rooms of patients with coronavirus disease 2019 (COVID-19) Infection Control & Hospital Epidemiology 2023;44:827-829	초록보기
  Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs Animals 2023;13(4):624	초록보기
  Characteristics and risk factors of prolonged viable virus shedding in immunocompromised patients with COVID-19: a prospective cohort study Journal of Infection 2023;86:412-414	초록보기
  Determinants of Functional MicroRNA Targeting Mol Cells 2023;46(1):21-32	초록보기
  Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron subvariants Antiviral Research 2023;214:105609	초록보기
  mRNA‐HPV vaccine encoding E6 and E7 improves therapeutic potential for HPV‐mediated cancers via subcutaneous immunization J Med Virol 2023;95(12):e29309	초록보기
  Mutational analysis of severe acute respiratory syndrome coronavirus 2 in immunocompromised patients with persistent viral detection using whole genome sequencing Clin Transl Med 2023;13:e1462	초록보기
  Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay Antiviral Research 2023;209:105473	초록보기
  Virological characteristics and the rapid antigen test as deisolation criteria in immunocompromised patients with COVID-19: A prospective cohort study J Med Virol 2023;95:e29228	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Adjuvant effect of IRES-based single-stranded RNA on melanoma immunotherapy BMC Cancer 2022;22(1):1-12	초록보기
  Antibody responses to SARS-CoV-2 in children with COVID-19 J Pediatric Infect Dis Soc 2022;11(6):267-273	초록보기
  Chemical screen uncovers novel structural classes of inhibitors of the papain-like protease of coronaviruses iScience 2022;25(10):105254	초록보기
  Clinical Characteristics of 40 Patients Infected With the SARS-CoV-2 Omicron Variant in Korea J Korean Med Sci 2022;37(3):e31	초록보기
  Clinical scoring system to predict viable viral shedding in patients with COVID-19 J Clin Virol 2022;157:105319	초록보기
  Comparing the Immunogenicity and Protective Effects of Three MERS-CoV Inactivation Methods in Mice Vaccines 2022;10(11):1843	초록보기
  Cynomolgus Macaque Model for COVID-19 Delta Variant Immune Netw 2022;22(6):e48	초록보기
  Duration of Humoral Immunity and Cross-Neutralizing Activity Against the Alpha, Beta, and Delta Variants After Wild-Type Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Prospective Cohort Study J Infect Dis 2022;226(6):975-978	초록보기
  Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection J Extracell Vesicles 2022;11(1):e12179	초록보기
  Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays Front Cell Infect Microbiol 2022;12(1):822599	초록보기
  Evaluation of In-Hospital Cluster of COVID-19 Associated With a Patient With Prolonged Viral Shedding Using Whole-Genome Sequencing J Korean Med Sci 2022;37(39):e289	초록보기
  Kinetics of Glycoprotein-Specific Antibody Response in Patients with Severe Fever with Thrombocytopenia Syndrome Viruses 2023;14(2):256	초록보기
  Kinetics of neutralizing antibodies against SARS-CoV-2 infection according to sex, age, and disease severity Scientific Reports 2022;12(1):13491	초록보기
  Longitudinal Analysis of Memory T-Cell Responses in Survivors of Middle East Respiratory Syndrome Clin Infect Dis 2022;75(4):596-603	초록보기
  One Year Follow-Up of COVID-19 Related Symptoms and Patient Quality of Life: A Prospective Cohort Study Yonsei Med J 2022;63(6):499-510	초록보기
  Persistence of the neutralizing antibody response after SARS-CoV-2 infection Clin Microbiol Infect 2022;28(4):614.e1-614.e4	초록보기
  Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea BMC Infec Dis 2022;22(1):1-12	초록보기
  Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Emerg Microbes Infect 2022;11(1):2315-2325	초록보기
  Prolonged viral shedding in severely ill patients infected with SARS-CoV-2 Delta variants: A retrospective cohort study J Infect 2022;85(1):90-122	초록보기
  Relationship between SARS-CoV-2 antibody titer and the severity of COVID-19 J Microbiol Immunol Infect 2022;55(6):1094-1100	초록보기
  Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells iScience 2022;25(12):105571	초록보기
  Single-stranded RNA adjuvant enhances the efficacy of 10-valent human papilloma virus-like particle vaccine Microbiol Immunol 2022;66(11):529-537	초록보기
  The Seroprevalence of SARS-CoV-2 in Children During Early COVID-19 Pandemic in Korea: A Nationwide, Population-Based Study J Korean Med Sci 2022;37(44):e314	초록보기
  The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infections Scientific Reports 2022;12(1):1260	초록보기
  Time Course Evaluation of Enzyme-Linked Immunosorbent Assays Based on Cell-Free Recombinant Proteins for Detection Assays Based on Cell-Free Recombinant Proteins for Detection of Antibodies against Middle East Respiratory Syndrome Coronavirus Microbiol Spectr 2022;10(6):e0295322	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Neutralizing antibodies to severe fever with thrombocytopenia syndrome virus among survivors, non-survivors and healthy residents in South Korea Front Cell Infect Microbiol 2021;11:649570	초록보기
  A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein Nature Communications 2021;12(1):288	초록보기
  A COVID-19 Exposure at a Dental Clinic Where Healthcare Workers Routinely Use Particulate Filtering Respirators Int J Environ Res Public Health 2021; 18(12):6481	초록보기
  Comparison of SARS-CoV-2 variant lethality in human angiotensin-converting enzyme 2 transgenic mice Virus Research 2021;305:198563	초록보기
  Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission Emerg Microbes Infect 2021;10(1):152-160	초록보기
  Decreased seasonal influenza during the COVID-19 pandemic in temperate countries Travel Med Infect Dis 2021;41:102057	초록보기
  Evaluation of Six Anti-SARS-CoV-2 Antibody Test Kits and Practical Approaches to Optimize the Diagnostic Performance J Microbiol Immunol Infect 2021;54(5):983-986	초록보기
  Impact on airborne virus behavior by an electric heat pump (EHP) operation in a restaurant during winter season Building and Environment 2021;200:107951	초록보기
  Re-estimation of basic reproduction number of COVID-19 based on the epidemic curve by symptom onset data Epidemiol Infect 2021;149:e53	초록보기

  해당 관련 논문목록과 초록보기 링크 제공

  Adverse impact of renin-angiotensin system blockade on the clinical course in hospitalized patients with severe COVID-19: a retrospective cohort study Scientific Reports 2020;10:20250	초록보기
  An infectious cDNA clone of a growth attenuated Korean isolate of MERS coronavirus KNIH002 in clade B Emerg Microbes Infect 2020;9(1):2714-2726	초록보기
  Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus PLoS ONE 2020;15(5):e0232757	초록보기
  Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea JCI insight 2020;5	초록보기
  Genetic characterization of Japanese Encephalitis virus genotype 5 isolated from patient, South Korea, 2015 Emerg Infect Dis 2020;26:1002-1006	초록보기
  Genetic diversity and evolutionary history of Korean isolates of severe fever with thrombocytopenia syndrome virus from 2013–2016 Archives of Virology 2020;165:2599-2603	초록보기
  Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients J Clin Med 2020;9(7):2268	초록보기
  Prolonged (6-Month) Shedding of Middle East Respiratory Syndrome Coronavirus RNA in the Sputum of a Lymphoma Patient Open Forum Infect Dis 2020;7(8):ofaa292	초록보기
  Serologic Evaluation of Healthcare Workers Caring for COVID-19 Patients in the Republic of Korea Front microbiol 2020;11:587613	초록보기
  The architecture of SARS-CoV-2 transcriptome Cell 2020;181:914-921	초록보기
  The Serial Interval of COVID-19 in Korea: 1,567 Pairs of Symptomatic Cases from Contact Tracing J Korean Med Sci 2020;35(50):e435	초록보기

• 「감염병 치료제 개발을 위한 시험⋅분석 및 수수료에 관한 고시」제정(’24년)
  
• 치료제 실용화
  • 민관협력을 통한 국내 코로나19 항체치료제 최초 상용화
    • (국제 3번째 항체치료제, 렉키로나주 Regdanvimab,’21)
    

    항체치료제(렉키로나주)의 SARS-CoV-2 바이러스(야생형 및 변이주) 증식 억제 결과

    

    코로나19 치료항체 관련 논문 Nature Communications, (2021)12:288

    

    렉키로나주 상품화

• 기술이전성과
  • 민관협력을 통한 국내 코로나19 항체치료제 최초 상용화
    

    메르스 코로나 바이러스 특이 감염 동물모델 기술이전

    

    코로나19 항체치료제(렉키로나주) 기술이전

• 특허권(출원)

  특허권(출원) 정보 연번 특허명 특허(출원)번호 출원/등록일 종류로 구성

  연번	특허명	특허(출원)번호	출원/등록일
  1	TIS-L Targeting Antiviral antisense oligonucleotide with ablity to inhibit viral replication of SARS-CoV-2	18/744,136(PCT)	2024-06-14
  2	Monoclonal antibody for spike protein of Middle East Respiratory Syndrome Coronavirus, and use thereof	17/952,308(PCT)	미국 등록결정
  3	니파바이러스 뉴클레오캡시드 항원에 특이적으로 결합하는 항체 및 이의 용도	10-2023-0050099	2023-04-17
  4	니파바이러스 뉴클레오캡시드 항원에 특이적으로 결합하는 항체 및 이의 용도	10-2023-0050100	2023-04-17
  5	SARS-CoV-2 증식억제효과를 보이는 TIS-L 표적 안티센스 올리고뉴클레오타이드	10-2023-0077680	2023-06-16
  6	중동호흡기증후군 코로나바이러스에 대한 T-세포 에피톱 기반의 펩타이드 백신 및 이의 용도	10-2023-0145728	2023-10-27
  7	사스 코로나바이러스2 중화를 위한 이뮤노글로불린 A 항체 및 이의 용도	10-2023-0149769	2023-11-02
  8	사스 코로나바이러스2 중화를 위한 이뮤노글로불린 A 항체 및 이의 용도	10-2023-0149770	2023-11-02
  9	중동호흡기증후군 코로나바이러스 및 이의 용도(1)	10-2022-0065876	2022.5.30
  10	중동호흡기증후군 코로나바이러스 및 이의 용도(2)	10-2022-0065877	2022.5.30
  11	사스 코로나바이러스 2 스파이크 항원에 특이적으로 결합하는 항체 및 이의 용도(1)	10-2022-0137585	2022.10.24.
  12	사스 코로나바이러스 2 스파이크 항원에 특이적으로 결합하는 항체 및 이의 용도(2)	10-2022-0137586	2022.10.24.
  13	사스 코로나바이러스 2 스파이크 항원에 특이적으로 결합하는 항체 및 이의 용도(3)	10-2022-0137587	2022.10.24.
  14	중증열성혈소판감소증후군 범용 백신 후보주의 불활성화 면역후보물질 및 이의 용도	10-2022-0027404	2022.03.03
  15	니파바이러스 퓨전 변이 단백질 및 이의 용도	10-2432567(등록)	2022.8.10
  16	Binding Molecule Having Neutralizing Activity Against SARS-Coronavirus-2	17/913,182(PCT)	2022.9.21
  17	Binding Molecule Having Neutralizing Activity Against SARS-Coronavirus-2	No.21774952.2(PCT)	2022.10.21
  18	Monoclonal Antibody for Spike Protein of Middle East Respiratory Syndrome Coronavirus, And Use Thereof	17/952,308(PCT)	2022.09.25