Distribution

Guide to the Distribution status and procedure of the sale of stem cell stocks

Cell lines available from the bank

Cell type	Cell line	Provider	Origin and establishment method	Culture condition
hESC	SNUhES3	Seoul National University	ㆍOrigin: human embryo ㆍRegistry Number : hES12010005	ㆍFeeder (STO) ㆍhPSC media
	SNUhES4	Seoul National University	ㆍOrigin: human embryo ㆍRegistry Number : hES12010006	ㆍFeeder (STO) ㆍhPSC media
	SNUhES31	Seoul National University	ㆍOrigin: human embryo ㆍRegistry Number : hES12010037	ㆍFeeder-free ㆍVN-E8
	CHA-hES15	CHA University	ㆍOrigin: human embryo ㆍRegistry Number : hES12010028	ㆍFeeder (STO) ㆍhPSC media
hiPSC (healty donor cell-derived)	hFmiPS1	KNIH	ㆍParental cell : Dermal fibroblast ㆍReprogram : modified RNA ㆍAbnormal karyotype	ㆍFeeder (STO) ㆍhPSC media
	hFmiPS2	KNIH	ㆍParental cell : Dermal fibroblast ㆍReprogram : modified RNA	ㆍFeeder-free ㆍVN-E8
	hFSiPS3-1	KNIH	ㆍParental cell : Dermal fibroblast ㆍReprogram : Sendai virus ㆍhFSiPS1 sub-line	ㆍFeeder-free ㆍVN-E8
	hUSiPS2	KNIH	ㆍParental cell : Urinal cell ㆍReprogram : Sendai virus	ㆍFeeder-free ㆍVN-E8
	hAdMSiPS1	KNIH	ㆍParental cell : Adipocyte-MSC, TALEN ㆍReprogram : Sendai virus	ㆍFeeder (STO) ㆍhPSC media
	CMC-hiPSC-003	The Catholic University of Korea	ㆍParental cell : Bone marrow ㆍReprogram : Sendai virus ㆍHLA-homozygote	ㆍFeeder-free ㆍVN-E8
	CMC-hiPSC-005	The Catholic University of Korea	ㆍParental cell : Cord blood ㆍReprogram : Sendai virus ㆍHLA-homozygote ㆍAbnormal karyotype	ㆍFeeder-free ㆍVN-E8
	CMC-hiPSC-009	The Catholic University of Korea	ㆍParental cell : Cord blood ㆍReprogram : Sendai virus ㆍHLA-homozygote	ㆍFeeder-free ㆍVN-E8
	CMC-hiPSC-011	The Catholic University of Korea	ㆍParental cell : Cord blood ㆍReprogram : Sendai virus ㆍHLA-homozygote	ㆍFeeder-free ㆍVN-E8
	CMC-hiPSC-022	The Catholic University of Korea	ㆍParental cell : Cord blood ㆍReprogram : Sendai virus ㆍHLA-homozygote	ㆍFeeder-free ㆍVN-E8
	NU01-EiPS07	KNIH	ㆍParental cell : Urinal cell ㆍReprogram : Episomal vector	ㆍFeeder-free ㆍVN-E8
	PB01-EiPS21	KNIH	ㆍParental cell : Peripheral blood cell ㆍReprogram : Episomal vector	ㆍFeeder-free ㆍVN-E8
Disease -Specific hiPSC	DKH005i-A	KNIH	ㆍParental cell : Peripheral blood cell ㆍReprogram : Sendai virus ㆍDisease : Eye disease, Senior Loken syndrome	ㆍFeeder-free ㆍVN-E8
	DKH090i-A	KNIH	ㆍParental cell : Peripheral blood ㆍReprogram : Sendai virus ㆍDisease : Eye disease, Leber congenital amaurosis	ㆍFeeder-free ㆍVN-E8
	LQT01-hiPSC	KNIH	ㆍParental cell : Peripheral blood ㆍReprogram : Sendai virus ㆍDisease : Heart-signaling disorder, long QT syndrome type 2, KCNH2 (c.453delC)	ㆍFeeder-free ㆍVN-E8
	LQT08-hiPSC	KNIH	ㆍParental cell : Peripheral blood ㆍReprogram : Sendai virus ㆍDisease : Heart-signaling disorder, long QT syndrome type 1, Brugada syndrome, KCNQ1 (c.569G>A)	ㆍFeeder-free ㆍVN-E8
Fluorescent protein-tagged hiPSC	NCRM5AS1-iCAGcGFP.c9	NIH-CRM (U.S)	ㆍGenetic modification (GFP), TALEN ㆍParental cell : Peripheral blood (CD34+) ㆍReprogram : Episomal vector	ㆍFeeder-free ㆍVN-E8
	CMC-003i-Nestin.EGFP	KNIH	ㆍGenetic modification (EGFP in Nestin gene), CRISPR/CAS9 ㆍParental cell : CMC-hiPSC-003	ㆍFeeder-free ㆍVN-E8
	CMC-003i-Pdx1.EGFP	KNIH	ㆍGenetic modification (EGFP in PDX1 gene), CRISPR/CAS9 ㆍParental cell : CMC-hiPSC-003	ㆍFeeder-free ㆍVN-E8
	PB01-EiPS21 (GFP-NLS7)	KNIH	ㆍGenetic modification (EGFP-NLS in AAVS1 site), CRISPR/CAS9 ㆍParental cell : PB01-EiPS21	ㆍFeeder-free ㆍStemFlex
	PB01-EiPS21(Ruby2)	KNIH	ㆍGenetic modification (Ruby in AAVS1 site), CRISPR/CAS9 ㆍParental cell : PB01-EiPS21	ㆍFeeder-free ㆍStemFlex
	PB01-EiPS21-EGFP04	KNIH	ㆍGenetic modification (EGFP in AAVS1 site), CRISPR/CAS9 ㆍParental cell : PB01-EiPS21	ㆍFeeder-free ㆍVN-E8
	PB01-EiPS21-EGFP05	KNIH	ㆍGenetic modification (EGFP in AAVS1 site), CRISPR/CAS9 ㆍParental cell : PB01-EiPS21	ㆍFeeder-free ㆍVN-E8
Gene-Edited hiPSC	hiPSC-TLR2KO	KNIH	ㆍGenetic modification (TLR2 knock-out), CRISPR/CAS9 ㆍ(parental cell) modified from hiPSC CMC-hiPSC-003 ㆍParental cell : CMC-hiPSC-003	ㆍFeeder-free ㆍVN-E8
	hiPSC-TLR3KO-A49	KNIH	ㆍGenetic modification (TLR3 knock-out), CRISPER/CAS9 ㆍParental cell : CMC-hiPSC-003	ㆍFeeder-free ㆍVN-E8
	hiPSC-TLR7KO-A59	KNIH	ㆍGenetic modification (TLR7 knock-out), CRISPER/CAS9 ㆍParental cell : CMC-hiPSC-003	ㆍFeeder-free ㆍVN-E8
	hiPSC-TLR8KO-A10	KNIH	ㆍGenetic modification (TLR8 knock-out), CRISPER/CAS9 ㆍParental cell : CMC-hiPSC-003	ㆍFeeder-free ㆍVN-E8
	hFSiPS1_DUSP6KO	KNIH	ㆍGenetic modification (DUSP6 knock-out), CRISPR/CAS9 ㆍParental cell : hFSiPS1	ㆍFeeder-free ㆍVN-E8
	hFSiPS1_DUSP6KOA	KNIH	ㆍGenetic modification (DUSP6 knock-out), CRISPR/CAS9 ㆍParental cell : hFSiPS1 hFSiPS1_DUSP6KO subline	ㆍFeeder-free ㆍVN-E8

* Footnote : temporaily unavailable for additional QC tests

Application to access human stem cell lines

Please contact the National Stem Cell Bank of Korea at nscb@korea.kr

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Address: 202, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, Korea (28160)

Question: nscb@korea.kr

Cell type	Cell line	Reference
hFSiPS1	SNUhES3	Oh SK et al. Derivation and characterization of new human embryonic stem cell lines: SNUhES1, SNUhES2, SNUhES3. Stem Cells. 2005 Feb;23(2):211-9.
		Lee J-Y et al. Registration of human embryonic stem cell lines: Korea, 2010. Osong Public Health Res Perspect. 2011 Sep;2(2):141-7
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	SNUhES4	Lee J-Y et al. Registration of human embryonic stem cell lines: Korea, 2010. Osong Public Health Res Perspect. 2011 Sep;2(2):141-7.
	SNUhES4	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	SNUhES31	Lee J-Y et al. Registration of human embryonic stem cell lines: Korea, 2010. Osong Public Health Res Perspect. 2011 Sep;2(2):141-7.
		Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020 Oct 29;10(1):18582.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
		Yoo DH et al. DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation. Sci Rep. 2023 Apr 7;13(1):5683.
	CHA-hES15	Hwnag ST et al. The expansion of human ES and iPSC cells on porous membranes and proliferating human adipose-derived feeder cells. Biomaterials. 2010 Nov;31(31):8012-21.
		Lee J-Y et al. Registration of human embryonic stem cell lines: Korea, 2010. Osong Public Health Res Perspect. 2011 Sep;2(2):141-7.
		Kim SJ et al. Generation of hematopoietics stem cells from human embryonic stem cells using a defined, stepwise, serumfree replacement free monolyer culture method. Blood Research. 2017 Mar;52(1):37-43.
		Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020 Oct 29;10(1):18582.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.

Cell type	Cell line	Reference
hiPSC(healty donor)	hFmiPS1	Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system. Stem Cell Res. 2017 Oct;24:148-150.
		Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020 Oct 29;10(1):18582.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	hFmiPS2	Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system. Stem Cell Res. 2017 Oct;24:148-150.
		Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020 Oct 29;10(1):18582.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	hFSiPS1/hFSiPS3-1	Kim JY et al. HDAC6 Inhibitors rescued the defective axonal mitochondrial movement in motor neurons derived from the induced pluripotent stem cells of peripheral neuropathy patient swith HSPB1 Mutation. Stem Cells Int. 2016 2016:9475981.
		Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a non-integration system. Stem Cell Res. 2017 May;21:13-15.
		Choi M et al. Multilayer Nanofilms via inkjet printing for stabilizing growth factor and designing desired cell developments. Adv Healthc Mater. 2017 Jul;6(14).
		Han U et al. Efficient encapsulation and sustained release of basic fibroblast growth factor in nanofilm : extension of the feeding cycle of human induced pluripotent stem cell culture. ACS Appl Mater Interfaces. 2017 Aug 2;9(30):25087-25097.
		Oh M et al. Promotive effects of human induced pluripotent stem cell-conditioned medium on the proliferation and migration of dermal fibroblasts. Biotechnol Bioproc E. 2017 Nov 22, 561-568.
		Oh M et al. Exosomes derived from human induced pluripotent stem cells ameliorate the aging of skin fibroblasts. Int J Mol Sci. 2018 Jun 9;19(6):1715.
		Han U et al. Construction of nano-scale cellular environments by coating a multilayer nanofilm on the surface of human induced pluripotent stem cells. Nanoscale. 2019 Jul 28;11(28):13541-13551.
		Lee H et al. Derivation of Cell-Engineered Nanovesicles from Human Induced Pluripotent Stem Cells and Their Protective Effect on the Senescence of Dermal Fibroblasts. Int J Mol Sci. 2020 Jan 5;21(1):343.
		Kim YK et al. Generation of a GLA knock-out human-induced pluripotent stem cell line, KSBCi002-A-1, using CRISPR/Cas9. Stem Cell Res. 2020 Jan;42:101676.
		Yoo DH et al. Simple differentiation method using FBS identifies DUSP6 as a marker for fine-tuning of FGF-ERK signaling activity in human pluripotent stem cells. Biochem Biophys Res Commun. 2020 Jan 8;521(2):375-382.
		Cha BH et al. Efficient Isolation and enrichment of mesenchymal stem cells from human embryonic stem cells by utilizing the Interaction between integrin 𝜶5𝜷1 and fibronectin. Adv Sci (Weinh). 2020 Jul 19;7(17):2001365.
		Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020 Oct 29;10(1):18582.
		특허출원 : 물리적 자극을 통한 심근세포 분화 성숙도 및 기능성 향상 방법, 출원인 : 한국화학연구원, 출원번호 : 10-2020-0189736, 출원일자 : 2020년 12월 31일
		Han U et al. Nano-structure of vitronectin/heparin on cell membrane for stimulating single cell in iPSC-derived embryoid body. iScience. 2021 Mar 11;24(4):102297.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
		Heo HR et al. Generation of marcrophage containing alveolar organoids derived from humna pluripotent stem cells for pulmonary fibrosis modeling and drug efficacy testing. Cell Biosci. 2021 Dec 18;11(1):216.
		Lee SJ et al. Improving Generation of Cardiac Organoids from Human Pluripotent Stem Cells Using the Aurora Kinase Inhibitor ZM447439. Biomedicines. 2021 Dec 20;9(12):1952.
		특허출원 :오로라 키나아제 억제제를 이용하는 심근세포 및 심장 오가노이드의 제조방법, 출원인 : 한국화학연구원, 출원번호 : 10-2021-0179903, 출원일자 : 2021년 12월 15일
		특허출원 : 줄기세포로부터 도파민 신경전구세포 분화 유도 방법, 출원인 : 조명수 등, 출원번호 : 10-2022-0049108, 출원일자 : 2022년 4월 20일
		특허출원 : DUSP6가 결핍된 줄기세포 및 이의 용도 (DUSP6 deficient stem cells and their use), 출원인 : 국립보건연구원장, 출원번호 : 10-2022-0073479, 출원일자 : 2022년 6월 16일
		Yoo DH et al. DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation. Sci Rep. 2023 Apr 7;13(1):5683.
	hUSiPS2	Uhm KO et al. Generation of human induced pluripotent stem cells from urinary cells of a healthy donor using a non-integration system. Stem Cell Res. 2017 May;21:44-46.
		Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020 Oct 29;10(1):18582.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	hAdMSiPS1	Choi HY et al. Generation of a human induced pluripotent stem cell line, KSCBi003-A, from human adipose tissue-derived mesenchymal stem cells using a chromosomal integration-free system. Stem Cell Res. 2018 Aug;31:1-4.
	hAdMSiPS1	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	CMC-hiPSC-003	특허출원 : HLA 동형접합체의 제대혈단핵구세포 유래 인간전분화능세포를 이용한 연골세포 분화용 조성물 제조방법, 출원인 : 주지현 등, 출원번호 : 10-2017-0178684, 출원일자 : 2017년 12월 22일
		Rim YA et al. Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea. J Tissue Eng Regen Med. 2018 Mar;12(3):e1531-e1536.
		Lim JJ et al. Maintenance of the PSCs under Xeno-Free and chemically defined culture conditions. Int J Stem Cells. 2019 Nov 30;12(3):484-496.
		Han HW. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13(6):980-991.
		Jeong S et al. BMP4 and perivascular cells promote hematopoietic differentiation of human pluripotent stem cells in a differentiation stage-specific manner. Exp Mol Med. 2020 Jan;52(1):56-65.
		Jo HY et al, Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives. Sci Rep. 2020 Mar 3;10(1):3939.
		Ha TW et al. Characterization of Endoplasmic Reticulum (ER) in Human Pluripotent Stem Cells Revealed Increased Susceptibility to Cell Death upon ER Stress. Cells. 2020 Apr 26;9(5):1078.
		특허출원 : 줄기세포 유래 자연살해세포 및 그 제조방법, 출원인 : 테라베스트, 출원번호 : 10-2020-0096415, 출원일자 : 2020년 7월 31일
		Mun SJ et al. Effect of microbial short-chain fatty acids on CYP3A4-mediated metabolic activation of human pluripotent stem cell-derived liver orgaoids. Cells. 2021 Jan 11;10(1):126.
		Han U et al. Nano-structure of vitronectin/heparin on cell membrane for stimulating single cell in iPSC-derived embryoid body. iScience. 2021 Mar 11;24(4):102297.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
		Jo HY et al. Single-Cell RNA Sequencing of Human Pluripotent Stem Cell-Derived Macrophages for Quality Control of The Cell Therapy Product.. Front Genet. 2022 Jan 31;12:658862.
		Kook MG et al. Generation of Cortical Brain Organoid with Vascularization by Assembling with Vascular Spheroid. Int J Stem Cells. 2022 Feb 28;15(1):85-94.
		Kim MJ et al. Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells. Organoid. 2022 May 2:e5.
		Kim J et al. Neurotoxicity of phenylalanine on human iPSC-derived cerebral organoids. Mol Genet Metab. 2022 Jun;136(2):132-144.
		Seo HR et al. Human pluripotent stem cell-derived alveolar organoid with macrophages. Int J Mol Sci. 2022 Aug 16;23(16):9211.
		Jung SY et al. Wnt-activating human skin organoid model of atopic dermatitis induced by Staphylococcus aureus and its protective effects by Cutibacterium acnes. iScience. 2022 Sep 16;25(10):105150.
		Kong D et al. Cortical-blood vessel assembloids exhibit Alzheimer's disease phenotypees by activating glia after SARS-CoV-2 infection. Cell Death Discov. 2023 Jan 25;9(1):32.
	CMC-hiPSC-005	특허출원 : HLA 동형접합체의 제대혈단핵구세포 유래 인간전분화능세포를 이용한 연골세포 분화용 조성물 제조방법, 출원인 : 주지현 등, 출원번호 : 10-2017-0178684, 출원일자 : 2017년 12월 22일
		Rim YA et al. Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea. J Tissue Eng Regen Med. 2018 Mar;12(3):e1531-e1536.
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	CMC-hiPSC-009	특허출원 : HLA 동형접합체의 제대혈단핵구세포 유래 인간전분화능세포를 이용한 연골세포 분화용 조성물 제조방법, 출원인 : 주지현 등, 출원번호 : 10-2017-0178684, 출원일자 : 2017년 12월 22일
		Rim YA et al. Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea. J Tissue Eng Regen Med. 2018 Mar;12(3):e1531-e1536.
		특허출원 : 세포 비접착성 PEG 고분자 기판 상에 형성된 심근세포 스페로이드 및 이의 제조방법, 출원인 : 이재혁 등, 출원번호 : 10-2019-0160657, 출원일자 : 2019년 12월 05일
		Jeong S et al. BMP4 and perivascular cells promote hematopoietic differentiation of human pluripotent stem cells in a differentiation stage-specific manner. Exp Mol Med. 2020 Jan;52(1):56-65.
		특허출원 : 줄기세포 유래 자연살해세포 및 그 제조방법, 출원인 : 테라베스트, 출원번호 : 10-2020-0096415, 출원일자 : 2020년 7월 31일
		Kim MJ et al. Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells. Organoid. 2022 May 2:e5.
	CMC-hiPSC-011	특허출원 : HLA 동형접합체의 제대혈단핵구세포 유래 인간전분화능세포를 이용한 연골세포 분화용 조성물 제조방법, 출원인 : 주지현 등, 출원번호 : 10-2017-0178684, 출원일자 : 2017년 12월 22일
		Rim YA et al. Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea. J Tissue Eng Regen Med. 2018 Mar;12(3):e1531-e1536.
		Kim Y et al. Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells. Stem Cell Res Ther. 2018 Aug 13;9(1):217.
		특허출원 : 인간 만능줄기세포로부터 제작된 3D 오가노이드를 해체하여 세포를 다량 확보하는 분화방법, 출원인 : 이상훈 등, 출원번호 : 10-2019-0128602, 출원일자 : 2019년 10월 16일
		Jeong S et al. BMP4 and perivascular cells promote hematopoietic differentiation of human pluripotent stem cells in a differentiation stage-specific manner. Exp Mol Med. 2020 Jan;52(1):56-65.
Choi SW et al. Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes. Antiviral Res. 2020 Dec;184:104955.
특허출원 : 인간만능줄기세포로부터 제작된 3D 오가노이드를 해체하여 세포를 다량 확보하는 분화방법, 출원인 : 이상훈 등, 출원번호 : PCT/KR2020/000581, 출원일자 : 2020년 1월 13일
특허출원 : 인간 전분화능줄기세포 유래 심근세포를 이용한 SARS-CoV-2 바이러스 대상 후보 약물의 부정맥 위험성 평가용 조성물 및 이를 이용한 부정맥 위험성 평가 방법, 출원인 : 문성환 등, 출원번호 : 10-2020-0081612, 출원일자 : 2020년 7월 2일
특허출원 : 인간 전분화능줄기세포 유래 심근세포를 이용한 SARS-CoV-2 바이러스 대상 후보 약물의 심근세포 독성평가용 조성물 및 이를 이요한 심근세포 독성 평가 방법, 출원인 : 문성환 등, 출원번호 : 10-2020-0084634, 출원일자 : 2020년 7월 9일
특허출원 : 동결보관 및 저산소 조건에서의 생존율을 향상시키는 심근세포 응집체 제작 기술, 출원인 : 문성환 등, 출원번호 : 10-2020-0091585, 출원일자 : 2020년 7월 23일
특허출원 : 동결보관 및 저산소 조건에서의 생존율을 향상시키는 심근세포 응집체 제작 기술, 출원인 : 문성환 등, 출원번호 : PCT/KR2020/011077, 출원일자 : 2020년 8월 14일
특허출원 : 인간 전분화능줄기세포 유래 심근세포를 이용한 SARS-CoV-2 바이러스 대상 후보 약물의 심근세포 독성평가용 조성물 및 이를 이요한 심근세포 독성 평가 방법, 출원인 : 문성환 등, 출원번호 : PCT/KR2020/016771, 출원일자 : 2020년 11월 25일
특허출원 : 인간 전분화능줄기세포 유래 심근세포를 이용한 SARS-CoV-2 바이러스 대상 후보 약물의 부정맥 위험성 평가용 조성물 및 이를 이용한 부정맥 위험성 평가 방법, 출원인 : 문성환 등, 출원번호 : PCT/KR2020/016777, 출원일자 : 2020년 11월 25일
특허등록 : 동결보관 및 저산소 조건에서의 생존율을 향상시키는 심근세포 응집체 제작 기술, 등록인 : 문성환 등, 등록번호 : 10-2188256, 등록일자 : 2020년 12월 02일
Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
Oh J, et al Establishment of a novel human iPSC line (YCMi003-A) from a patient with dilated cardiomyopathy carrying genetic varient LMNA p.Asp364His. Stem Cell Res. 2021 Oct;56:102508.
Lee SH et al. Generation of a human induced pluripotent stem cell line YCMi004-A from a patient with dilated cardiomyopathy carrying a protein-truncating mutation of the Titin gene and its differentiation towards cardiomyocytes. Stem Cell Res. 2021 Dec 16;59:102629.
특허출원 : 인간 전분화능줄기세포 유래 심근세포를 이용한 약물의 부정맥 위험성 평가 방법, 출원인 : 문성환 등, 출원번호 : 10-2021-0071052, 출원일자 : 2021년 6월 1일
특허출원 : 인간 전분화능줄기세포 유래 심근세포를 이용한 약물의 부정맥 위험성 평가 방법, 출원인 : 문성환 등, 출원번호 : PCT/KR2021/008305, 출원일자 : 2021년 6월 30일
Park SJ et al. Effect and application of cryopreserved three-dimensional microcardiac spheroids in myocardial infarction therapy. Clin Transl Med. 2022 Jan;12(1):e721.
Ye E et al. Effect of duty cycles of tumor-treating fields on glioblastoma cells and normal brain organoids,International journal of oncology. Int J Oncol. 2022 Jan;60(1):8.
Kook MG et al. Generation of Cortical Brain Organoid with Vascularization by Assembling with Vascular Spheroid. Int J Stem Cells. 2022 Feb 28;15(1):85-94.
Cha YJ et al. Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1(p.Glu192Lys). Stem Cell Res. 2022 Apr;60:102707.
Lee JY et al. Human palatine tonsils are linked to alzheimer's disease through function of reservoir of amyloid beta protein associated with bacterial infection. Cells. 2022 Jul 24;11(15):2285.
Kang JY et al. Generation of a heterozygous TPM1-E192K knock-in human induced pluripotent stem cell line using CRISPR/Cas9 system. Stem Cell Res. 2022 Aug;63:102878.
Jung SY et al. Wnt-activating human skin organoid model of atopic dermatitis induced by Staphylococcus aureus and its protective effects by Cutibacterium acnes. iScience. 2022 Sep 16;25(10):105150.
Mun D et al. Generation of two PITX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9 system,. Stem Cell Res. 2022 Dec;65:102940.
Jeon SB et al. Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C>T (p.Arg205Trp) variant of the TNN2 gene. Stem Cell Res. 2023 Mar;67:103048.
CMC-hiPSC-022	특허출원 : HLA 동형접합체의 제대혈단핵구세포 유래 인간전분화능세포를 이용한 연골세포 분화용 조성물 제조방법, 출원인 : 주지현 등, 출원번호 : 10-2017-0178684, 출원일자 : 2017년 12월 22일
CMC-hiPSC-022	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
NU01-EiPS07	Im YS et al. Generation of integration-free induced pluripotent stem cell line (KSCBi012-A) from urinary epithelial cells of a healthy male individual. Stem Cell Res. 2022 Aug;63:102841.
PB01-EiPS21	Im YS et al. Generation of integration-free induced pluripotent stem cell line (KSCBi017-A) from peripheral blood mononuclear cells of a healthy male individual. Stem Cell Res. 2022 Dec;65:102965.

Cell type	Cell line	Reference
Disease -Specific hiPSC	DKH005i-A	Park et al. Generation of human induced pluripotent stem cells from peripheral blood mononuclear cells of a Senior-Loken syndrome patient. Stem Cell Res. 2019 Dec;41:101648.
	DKH005i-A	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	DKH090i-A	Park et al. Generation of a human induced pluripotent stem cell line from a patient with Leber congenital amaurosis. Stem Cell Res. 2020 Mar;43:101725.
	DKH090i-A	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	LQT01-hiPSC	Lee Y et al. Establishment of a human induced pluripotent stem cell line, KSCBi015-A, from a long QT syndrome type 2 patient harboring a KCNH2 mutation. Stem Cell Res. 2021 Oct 13;57:102570.
	LQT08-hiPSC	Lee Y et al. Establishment of a human induced pluripotent stem cell line, KSCBi015-A, from a long QT syndrome type 1 patient harboring a KCNQ1 mutation. Stem cell research. 2021 Oct;56:102521.

Cell type	Cell line	Reference
Fluorescent protein-tagged hiPSC	NCRM5AS1-iCAGcGFP.c9	Luo et al. Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases. Stem Cells Transl Med. 2014 Jul;3(7):821-35.
		특허출원 : 대뇌 오가노이드-모터뉴런 스페로이드 구조체 및 이의 제조방법, 출원인 : 최정우 등, 출원번호 : 10-2020-0154027, 출원일자 2020년 11월 17일
		Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	CMC-003i-Nestin.EGFP	Lee Y et al. Generation of a NESTIN-EFGP reporter human induced pluripotent stem cell line, KSCBi005-A-1, using CRISPR/Cas9 nuclease. Stem. Cell Res. 2019 Oct;40:101554.
	CMC-003i-Nestin.EGFP	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.
	CMC-003i-Pdx1.EGFP	Lee Y et al. Generation of a PDX1-EFGP reporter human induced pluripotent stem cell line, KSCBi005-A-3, using CRISPR/Cas9 system. Stem Cell Res. 2019 Dec;41:101632.
	CMC-003i-Pdx1.EGFP	Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021 May;53:102270.

Cell type	Cell line	Reference
Gene-Edited hiPSC	hiPSC-TLR2KO	Han HJ et al. Generation of a TLR2 knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2021 Oct 19;57:102578.
	hiPSC-TLR3KO-A49	Han HJ et al. Establishment of a TLR3 homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2021 Apr;52:102187.
	hiPSC-TLR7KO-A59	Han HJ et al. Generation of a TLR7 homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2019 Oct;40:101520.
	hiPSC-TLR8KO-A10	Han HJ et al. Generation of a KSCBi005-A-5(TLR8KO-A10) homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2019 Oct;40:101561.
	hFSiPS1_DUSP6KO	특허출원 : DUSP6가 결핍된 줄기세포 및 이의 용도 (DUSP6 deficient stem cells and their use), 출원인 : 국립보건연구원장, 출원번호 : 10-2022-0073479, 출원일자 : 2022년 6월 16일
	hFSiPS1_DUSP6KO	Yoo DH et al. DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation. Sci Rep. 2023 Apr 7;13(1):5683.
	hFSiPS1_DUSP6KOA	특허출원 : DUSP6가 결핍된 줄기세포 및 이의 용도 (DUSP6 deficient stem cells and their use), 출원인 : 국립보건연구원장, 출원번호 : 10-2022-0073479, 출원일자 : 2022년 6월 16일
	hFSiPS1_DUSP6KOA	Yoo DH et al. DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation. Sci Rep. 2023 Apr 7;13(1):5683.

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)


RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
RNA-seq
Methyl-seq

Type	Link
SNP chip(CNV)
WES(SNP&INDEL)
RNA-seq
RNA-seq
Methyl-seq

Stem Cell·Regenerative Medicine

National research infrastructure

Distribution

Cell lines available from the bank

Application to access human stem cell lines

Stem Cell·Regenerative Medicine

National research infrastructure

Distribution

Cell lines available from the bank

Application to access human stem cell lines

hESC

hiPSC(healty donor)

Disease-Specific hiPSC

Fluorescent protein-tagged hiPSC

Gene-Edited hiPSC

NGS data - SNUhES31

NGS data - CHA-hES15

NGS data - hFmiPS1

NGS data - hFmiPS2

NGS data - hFSiPS3-1

NGS data - hUSiPS2

NGS data - hAdMSiPS1

NGS data - CMC-hiPSC-003

NGS data - CMC-hiPSC-005

NGS data - CMC-hiPSC-009

NGS data - CMC-hiPSC-011

NGS data - CMC-hiPSC-022

NGS data - NU01-EiPS07

NGS data - PB01-EiPS21

NGS data - DHK-005iA

NGS data - DHK-090iA

NGS data - NCRM5AS1-iCAGcGFP.c9

NGS data - CMC-003i-Nestin.EGFP

NGS data - CMC-003i-Pdx1.EGFP

NGS data - hFSiPS1_DUSP6KO

NGS data - hFSiPS1_DUSP6KOA