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- Date2021-02-23 16:09
- Update2021-02-23 16:09
- CountersignatureDivision of Research Planning
Alzheimers & dementia, 2020.16(11), 1504-1514, DOI: https://doi.org/10.1002/alz.12150.
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients
Sofia Finsterwalder, Benno Gesierich; Miguel Á Araque Caballero; Nick A Weaver; Nicolai Franzmeier; Marios K Georgakis; Marek J Konieczny; Huiberdina L Koek; Celeste M Karch; Neill R Graff-Radford; Stephen Salloway; Hwamee Oh; Ricardo F Allegri; Jasmeer P Chhatwal; Frank Jessen; Emrah Düzel; Laura Dobisch; Coraline Metzger; Oliver Peters; Enise I Incesoy; Josef Priller; Eike J Spruth; Anja Schneider; Klaus Fließbach; Katharina Buerger; Daniel Janowitz; Stefan J Teipel; Ingo Kilimann; Christoph Laske; Martina Buchmann; Michael T Heneka; Frederic Brosseron; Annika Spottke; Nina Roy; Birgit Ertl-Wagner; Klaus Scheffler; Sang Won Seo; Yeshin Kim; Duk L Na; Hee Jin Kim; Hyemin Jang; Michael Ewers; Johannes Levin; Reinhold Schmidt; Ofer Pasternak; Martin Dichgans; Geert Jan Biessels; Marco Duering
Introduction: Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations.
Methods: We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures.
Results: SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant.
Discussion: In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
- DOI: https://doi.org/10.1002/alz.12150.
- ISBN or ISSN: 1552-5260
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.