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Elevated Cerebrospinal Fluid and Plasma N-Cadherin in Alzheimer Disease
  • Date2021-02-23 16:05
  • Update2021-02-23 16:05
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

Journal of Neuropathology and Experimental Neurology, 2020.79, 484-492, DOI: https://doi.org/10.1093/jnen/nlaa019


Elevated Cerebrospinal Fluid and Plasma N-Cadherin in Alzheimer Disease

Ji-Young Choi, Sun-Jung Cho; Jung Hyun Park; Sang-Moon Yun; Chulman Jo; Eun-Joo Kim; Gi Yeong Huh; Moon Ho Park; Changsu Han; Young Ho Koh


Abstract

    N-cadherin is a synaptic adhesion molecule stabilizing synaptic cell structure and function. Cleavage of N-cadherin by c-secretase produces a C-terminal fragment, which is increased in the brains of Alzheimer disease (AD) patients. Here, we investigated the relationship between fluid N-cadherin levels and AD pathology. We first showed that the cleaved levels of N-cadherin were increased in homogenates of postmortem brain from AD patients compared with that in non-AD patients. We found that cleaved N-cadherin levels in the cerebrospinal fluid were increased in AD dementia compared with that in healthy control. ELISA results revealed that plasma levels of N-cadherin in 76 patients with AD were higher than those in 133 healthy control subjects. The N-cadherin levels in the brains of an AD mouse model, APP Swedish/PS1delE9 Tg (APP Tg) were reduced compared with that in control. The N-terminal fragment of N-cadherin produced by cleavage at a plasma membrane was detected extravascularly, accumulated in senile plaques in the cortex of an APP Tg mouse. In addition, N-cadherin plasma levels were increased in APP Tg mice. Collectively, our study suggests that alteration of N-cadherin levels might be associated with AD pathology.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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