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Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study...
  • Date2021-02-23 16:04
  • Update2021-02-23 16:04
  • CountersignatureDivision of Research Planning
  • Tel043-719-8033

BMJ Open, 2020.10, e035725-0, DOI: https://doi.org/10.1136/bmjopen-2019-035725


Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

Minkyeong Kim, Sang-Moon Yun; Jihyun Jeong; Chulman Jo; Young Ho Koh


Abstract

    Objectives

    Although lead is a potential risk factor for cardiovascular diseases such as stroke, research on this association in the Korean population remains limited.
    Therefore, we aimed to investigate the association between lead level and stroke in Korean adults.
    Design

    A population-based cross-sectional study.
    Setting The Korea National Health and Nutrition Examination Survey 2008–2013, which enrolled a representative sample of the Korean population.
    Participants

    We excluded participants younger than 20 years, missing weight data, pregnant or lactating, and missing blood lead and stroke data. A total of 11 510 participants were included in this analysis.
    Primary and secondary outcome measurement The participants were classified by blood lead concentration into the low-level (≤2.189 μg/dL, n=5756) and high-level (>2.189 μg/dL, n=5754) groups. The main outcome, stroke, was assessed by information from physician diagnosis, prevalence of stroke or treatment for stroke.
    The ORs and 95% CIs were calculated to evaluate the association between blood lead level and stroke using multivariate logistic regression analysis.
    Results

    Although blood lead level was not significantly associated with stroke (OR: 1.30, 95% CI: 0.66–2.58) in the multivariate-adjusted model, in individuals with hypertension, the high-level group was 2.36-fold higher odds of stroke (OR: 2.36, 95% CI: 1.02–5.44) compared to that in the low-level group. No association was observed in individuals with normotension (OR: 0.42, 95% CI: 0.13– 1.38, p for interaction=0.007).
    Conclusion

    The association between blood lead concentration and stroke may be influenced by hypertension status. Our findings suggest the need for closer attention to lead exposure in patients with hypertension.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


This public work may be used under the terms of the public interest source This public work may be used under the terms of the public interest source
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