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Medicina, 2020.56(5), 239-0, DOI: https://doi.org/10.3390/medicina56050239
Clinical Characteristics of Mitochondrial DNA Copy Number in Osteonecrosis of the Femoral Head
Lee SW, Lee KJ;Kim BS;Kwon HJ;Lee JH
Background and objectives: Alterations in mitochondrial DNA (mtDNA) have been observed and studied in various diseases. However, the clinical value of the mtDNA copy number (mtDNA-CN) alterations in osteonecrosis of the femoral head (ONFH) is poorly understood. In the present study, weinvestigated whether alterations inmtDNA-CNsare associated with clinicopathological parameters in ONFH.
Materials and methods: MtDNA-CNs in the synovial tissue of 34 patients with ONFH and 123 control tissues (femoral neck fracture) were measured using quantitative real-time PCR.
The present study then analyzed the correlation between the mtDNA-CN and the clinicopathological characteristics of ONFH and fracture patients.
Results: The average mtDNA-CN (mean standard deviation) was 23.82 22.37 and 25.04 24.27 in ONFH and control tissues, respectively, and was not significantly di erent between the groups (p = 0.792). The mtDNA-CN was positively associated with age (27.7% vs. 45.9%, p = 0.018) and negatively associated with the erythrocyte sedimentation rate (ESR) (11.8% vs. 39.7%, p = 0.024) in all of the samples. The study also found further associations with age (22.2% vs. 68.8%, p = 0.014), gender (30.0% vs. 64.3%, p = 0.048), and ESR (0% vs. 57.7%, p = 0.043) in ONFH.
Conclusions: in this study, we demonstrated that mtDNA-CN might be a significant marker for predicting clinical characteristics in ONFH.
- DOI: https://doi.org/10.3390/medicina56050239
- ISBN or ISSN: 1010-660X
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.