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Cancers, 2020.12(9), E2705-0, DOI: https://doi.org/10.3390/cancers12092705
Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients
Kim B, Cho E., Yoon JH, Kim S, Cheong J, Cho S, Park T
Hepatocellular carcinoma (HCC) is one of the diseases associated with human microbiome. The human microbiome is known to a ect human disease through the metabolites.
The aim of this study was to identify the pathways associated withHCCby integrating microbiome and metabolomic data via a novel pathway-based integrative method named HisCoM-MnM representing Hierarchical structural Component Model for pathway analysis of Microbiome and Metabolome.
Application of HisCoM-MnM to datasets from HCC and liver cirrhosis (LC) patients successfully identified HCC-related pathways related to cancer metabolic reprogramming along with the significant metabolome and metagenome that make up those pathways.
- DOI: https://doi.org/10.3390/cancers12092705
- ISBN or ISSN: 2072-6694
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.