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Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma..
  • 작성일2021-02-22
  • 최종수정일2021-02-22
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 202

Cancers, 2020.12(9), E2705-0, DOI: https://doi.org/10.3390/cancers12092705


Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients

Kim B, Cho E., Yoon JH, Kim S, Cheong J, Cho S, Park T


Abstract

    Hepatocellular carcinoma (HCC) is one of the diseases associated with human microbiome. The human microbiome is known to a ect human disease through the metabolites.
    The aim of this study was to identify the pathways associated withHCCby integrating microbiome and metabolomic data via a novel pathway-based integrative method named HisCoM-MnM representing Hierarchical structural Component Model for pathway analysis of Microbiome and Metabolome.
    Application of HisCoM-MnM to datasets from HCC and liver cirrhosis (LC) patients successfully identified HCC-related pathways related to cancer metabolic reprogramming along with the significant metabolome and metagenome that make up those pathways.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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