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Biochemical and biophysical research communications, 2020.522(3), 731-735, DOI: https://doi.org/10.1016/j.bbrc.2019.11.112
Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis
Lee B, Song YS;Rhodes C;Goh TS;Roh JS;Jeong H;Park J;Lee HN;Lee SG;Kim S;Kim M;Lee SI;Sohn DH;Robinson WH
Rheumatoid arthritis (RA) is a highly inflammatory autoimmune disease. Although proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin (IL)-6, play a key role in the pathogenesis of RA, the causes of chronic inflammation are not fully understood. Here, we report that protein phosphatase magnesium-dependent 1A (PPM1A) levels were increased in RA synovial fluid compared with osteoarthritis (OA) synovial fluid and positively correlated with TNF levels. In addition, PPM1A expression was increased in synovial tissue from RA patients and joint tissue from a mouse model of arthritis. Finally, extracellular PPM1A induced inflammation by stimulating macrophages to produce TNF through toll-like receptor 4 (TLR4) and myeloid differentiation primary response protein 88 (MyD88) signaling pathway. Our findings suggest that extracellular PPM1A may contribute to the pathogenesis of RA by functioning as a damage-associated molecular pattern (DAMP) to induce inflammation.
- DOI: https://doi.org/10.1016/j.bbrc.2019.11.112
- ISBN or ISSN: 0006-291X
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.