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The Korean journal of internal medicine, 2020.35(4), 929-935, DOI: https://doi.org/10.3904/kjim.2018.417
The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers
Yoo S, Kang HG;Choi J;Hong M;Do S;Lee J;Lee W;Lee S;Lee J;Cha S;Kim C;Lee E;Park J
Background/Aims: Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers.
Methods: This study included 714 lung cancer patients and 626 healthy controls.
The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay.
Results: Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma.
Conclusions: These results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.
- DOI: https://doi.org/10.3904/kjim.2018.417
- ISBN or ISSN: 1226-3303
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.