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Multiple Sclerosis Journal, 2020.N, 0-0, DOI: https://doi.org/doi: 10.1177/1352458520948213
Comparison of MOG and AQP4 Antibody Seroprevalence in Korean Adults with Inflammatory Demyelinating CNS Diseases
Jae-Won Hyun, Hye Lim Lee;Woo Kyo Jeong;Hye Jung Lee;Jong Hwa Shin;Ju-Hong Min;Byoung Joon Kim;Seung Woo Kim;Ha Young Shin;Jeeyoung Oh;Woojun Kim;Hyun-June Shin;Sun-Young Oh;Hyunjin Kim;Young-Min Lim;So-Young Huh;Eun Bin Cho;Tai-Seung Nam;Seung-Han Lee;Sun-Young Kim;Sa-Yoon Kang;Suk Geun Han;Eun Hee Sohn;Seol-Hee Baek;Byung-Jo Kim;Sang-Soo Lee;Jin Myoung Seok;Yoon-Ho Hong;Seong-il Oh;Jong Kuk Kim;Kyong Jin Shin;Ohyun Kwon;Joong-Yang Cho;Jong Seok Bae;So Yeon Kim;Yeseul Kim;Min Young Lee;Su-Hyun Kim and Ho Jin Kim
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.
- DOI: https://doi.org/doi: 10.1177/1352458520948213
- ISBN or ISSN: 1352-4585
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.