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Physicochemical Properties in Three-Dimensional Hydrogel Modulate Cellular Reprogramming into ....
  • 작성일2021-02-17
  • 최종수정일2021-02-17
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 61

Advanced Functional Materials, 2020.2007041, 0-0, DOI: https://doi.org/10.1002/adfm.202007041


Physicochemical Properties in Three-Dimensional Hydrogel Modulate Cellular Reprogramming into Induced Pluripotent Stem Cells

Deogil Kim, Byung-Hyun Cha; Jinsung Ahn; Yoshie Arai; Bogyu Choi


Abstract

    Understanding the biophysical relationships between stem cells and applied biomaterials can facilitate the ability to control the functions and behaviors of stem cells. However, the role of 3D microenvironment in stem cell biology remains largely unexplored, compared with that of 2D cell‐culture environment. Here, a new strategy that improves the efficacy of Yamanaka's four‐factor‐induced cellular reprogramming into induced pluripotent stem cells (iPSCs) by incorporating cues derived from the 3D microenvironment and biophysical ligands is reported. Among the various 3D hydrogel systems tested, methacrylated hyaluronic acid (HA) hydrogel significantly improves cellular reprogramming into iPSCs. Additionally, the initial upregulation of CD44 in encapsulated cells in low‐level methacrylated soft HA hydrogel accelerates the reprogramming. In conclusion, the reported HA hydrogel with low modulus accelerates reprogramming into iPSCs and thus offers potential advantages for translational applications.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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