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Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea
  • 작성일2021-02-17
  • 최종수정일2021-02-17
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 62

BMC Infectious disease, 2020.20(421), 1-5, DOI: https://doi.org/10.1186/s12879-020-05130-3


Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea

Seung Hun Lee, Jae Hoon Lee;Sungdo Park;Hae Kyung Lee;Seon Do Hwang;Hye Won Jeong;Jung Yeon Heo;Yeong Seon Lee


Abstract

    Background: The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Korea. Case

    Presentation: Two adult patients with fever had serologic tests against C. burnetii initially negative, and polymerase chain reaction against 16S rRNA using whole blood was also negative. After bacterial amplification of C. burnetii in immune-depressed mice, we isolated C. burnetii from patients with acute Q fever. The isolates KZQ2 and KZQ3 were confirmed by polymerase chain reaction, nucleotide sequence analysis, and morphologic observation using a transmission electron microscope.

    Conclusions: These results can help us understand the clinical and epidemiologic features of Q fever in South Korea.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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