Journal of Infectious Diseases, 2020.n, 0-0, DOI: https://doi.org/https://doi.org/10.1093/infdis/jiaa466

Factors Associated With Viral Load Kinetics of Middle East Respiratory Syndorme Coronavirus During the 2015 Outbreak in South korea

Jeong-Sun Yang, Min-Gyu Yoo;Hye-Ja Lee;Han Byul Jang;Hee-Dong Jung;Jeong-Gu Nam,;Joo-Yeon Lee;Youngmee Jee;Sung Soon Kim

Abstract

We conducted a retrospective study of Middle East respiratory syndrome coronavirus (MERS-CoV) viral load kinetics using data from patients hospitalized with MERS-CoV infection between 19 May and 20 August 2015. Viral load trajectories were considered over the hospitalization period using 1714 viral load results measured in serial respiratory specimens of 185 patients. The viral load levels were significantly higher among nonsurvivors than among survivors (P = .003). Healthcare workers (P = .001) and nonspreaders (P < .001) had significantly lower viral loads. Viral RNA was present on the day of symptom onset and peaked 4–10 days after symptom onset.

• DOI: https://doi.org/https://doi.org/10.1093/infdis/jiaa466
• ISBN or ISSN: 0022-1899

• 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
• This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.