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Annals of Surgical Treatment and Research, 2019. 96(4), 153-161, DOI: https://doi.org/10.4174/astr.2019.96.4.153
Genetic Features associated with 18F-FDG uptake in intrahepatic cholangiocarcinoma
Keun Soo Ahn, Jeong Woo Lee;Kyoung Sook Won;Koo Jeong Kang;Yong Hoon Kim;Tae-Seok Kim;Bong-Il Song;Hae Won Kim;Daniel O'Brien;Lewis R Roberts
Purpose: In intrahepatic cholangiocarcinoma (iCCA), genetic characteristics on 18F-fluorodeoxyglucose (18F-FDG)-PETscans are not yet clarified. If specific genetic characteristics were found to be related to FDG uptake in iCCA, we can predictmolecular features based on the FDG uptake patterns and to distinguish different types of treatments. In this purpose, weanalyzed RNA sequencing in iCCA patients to evaluate gene expression signatures associated with FDG uptake patterns.Methods: We performed RNA sequencing of 22 cases iCCA who underwent preoperative 18F-FDG-PET, and analyzed theclinical and molecular features according to the maximum standard uptake value (SUVmax). Genes and biological pathwaywhich are associated with SUVmax were analyzed.Results: Patients with SUVmax higher than 9.0 (n = 9) had poorer disease-free survival than those with lower SUVmax (n =13, P = 0.035). Genes related to glycolysis and gluconeogenesis, phosphorylation and cell cycle were significantly correlatedwith SUVmax (r ≥ 0.5). RRM2, which is related to the toxicity of Gemcitabine was positively correlated with SUVmax, andSLC27A2 which is associated with Cisplastin response was negatively correlated with SUVmax. According to the pathwayanalysis, cell cycle, cell division, hypoxia, inflammatory, and metabolism-related pathways were enriched in high SUVmaxpatients.Conclusion: The genomic features of gene expression and pathways can be predicted by FDG uptake features in iCCA.Patients with high FDG uptake have enriched cell cycle, metabolism and hypoxic pathways, which may lead to a morerational targeted treatment approach.
- DOI: https://doi.org/10.4174/astr.2019.96.4.153
- ISBN or ISSN: 2288-6575
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.