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Establishment of the Seoul National University Prospectively Enrolled Registry for Genitourinary ...
  • 작성일2020-08-07
  • 최종수정일2020-08-07
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 944

Investigative and clinical urology, 2019. 60(4), 235-243, DOI: https://doi.org/10.4111/icu.2019.60.4.235


Establishment of the Seoul National University Prospectively Enrolled Registry for Genitourinary Cancer (SUPER-GUC)_A prospective, multidisciplinary, bio-bank linked cohort and research platform

Chang Wook Jeong, Jungo Suh;Hyeong Dong Yuk;Bum Sik Tae;Miso Kim;Bhumsuk Keam;Jin Ho Kim;Sang Youn Kim;Jeong Yeon Cho;Seung Hyup Kim;Kyung Chul Moon;Gi Jeong Cheon;Ja Hyeon Ku;Hyeon Hoe Kim;Cheol Kwak


Abstract

    Purpose: To establish a prospective, comprehensive, multidisciplinary, bio-bank linked genitourinary cancer cohort based on standardreal practice.

    Materials and Methods: We established the Seoul National University Prospectively Enrolled Registry for Genitourinary Cancer(SUPER-GUC), a prospective cohort clinical database and bio-specimen repository system for prostate cancer (SUPER-PC), renalcell carcinoma (SUPER-RCC), and urothelial cancer (SUPER-UC) at a high-volume, tertiary institution. Each cohort consists of severalsub-cohorts based on treatment or disease status. Detailed longitudinal clinical information, and general and disease specificpatient-reported outcomes are captured. We use the same evaluation format and questionnaires for all participating departments.Patients’ blood, urine, tumor, and normal tissues are collected. The number of registered patients and their basic characteristics aresummarized. For the surgical sub-cohort, study participation, bio-specimen, and tissue banking rates are analyzed.

    Results: Since March 2016, 11 sub-cohorts for all disease statuses have been opened, ranging from low-risk localized to metastaticdisease. SUPER-PC, SUPER-RCC, and SUPER-UC enrolled 929, 796, and 1,221 patients, respectively. Study participation, biosampling,and fresh frozen tumor banking rates of surgical sub-cohorts were 89.0% to 93.1%, 91.2% to 99.1%, and 56.9% to 79.1%,respectively.

    Conclusions: SUPER-GUC is a study platform for comparative outcome, quality-of-life, and translational (genetics, biomarkers) researchfor genitourinary cancer.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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