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Frontiers in Aging Neuroscience, 2019. 01, 1-12, DOI: https://doi.org/10.3389/fnagi.2019.00147
Distinct Brain Regions in Physiological and Pathological Brain Aging
Jin San Lee, Yu Hyun Park;Seongbeom Park;Uicheul Yoon;Yeongsim Choe;Bo Kyoung Cheon;Alice Hahn;Soo Hyun Cho;Seung Joo Kim;Jun Pyo Kim;Young Hee Jung;Key-Chung Park;Hee Jin Kim;Hyemin Jang;Duk L. Na; and Sang Won Seo
Background: Studying structural brain aging is important to understand age-relatedpathologies, as well as to identify the early manifestations of the Alzheimer’s disease(AD) continuum. In this study, we investigated the long-term trajectory of physiologicaland pathological brain aging in a large number of participants ranging from the 50s toover 80 years of age.
Objective: To explore the distinct brain regions that distinguish pathological brain agingfrom physiological brain aging using sophisticated measurements of cortical thickness.
Methods: A total of 2,823 cognitively normal (CN) individuals and 2,675 patientswith AD continuum [874 with subjective memory impairment (SMI), 954 with amnesticmild cognitive impairment (aMCI), and 847 with AD dementia] who underwent a highresolution3.0-tesla MRI were included in this study. To investigate pathological brainaging, we further classified patients with aMCI and AD according to the severity ofcognitive impairment. Cortical thickness was measured using a surface-based method.Multiple linear regression analyses were performed to evaluate age, diagnostic groups,and cortical thickness.
Results: Aging extensively affected cortical thickness not only in CN individuals but alsoin AD continuum patients; however, the precuneus and inferior temporal regions wererelatively preserved against age-related cortical thinning. Compared to CN individuals,AD continuum patients including those with SMI showed a decreased cortical thicknessin the perisylvian region. However, widespread cortical thinning including the precuneusand inferior temporal regions were found from the late-stage aMCI to the moderate tosevere AD. Unlike the other age groups, AD continuum patients aged over 80 yearsshowed prominent cortical thinning in the medial temporal region with relative sparingof the precuneus.Frontiers in Aging Neuroscience | www.frontiersin.org 1 June 2019 | Volume 11 | Article 147Lee et al. Physiological and Pathological Brain Aging
Conclusion: Our findings suggested that the precuneus and inferior temporal regionsare the key regions in distinguishing between physiological and pathological brain aging.Attempts to differentiate age-related pathology from physiological brain aging at a veryearly stage would be important in terms of establishing new strategies for preventingaccelerated pathological brain aging.
Keywords: physiological brain aging, pathological brain aging, cortical thickness
- DOI: https://doi.org/10.3389/fnagi.2019.00147
- ISBN or ISSN: 1663-4365
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.