PLoS One, 2019. 14(11), e0224941-, DOI: https://doi.org/10.1371/journal.pone.0224941

Altered expression of Notch1 in Alzheimer's disease

Sun-Jung Cho, Sang-Moon Yun;Chulman Jo;Jihyun Jeong;Moon Ho Park;Changsu Han;Young Ho Koh

Abstract

Notch signaling is an evolutionarily conserved pathway that regulates cell-cell interactionsthrough binding of Notch family receptors to their cognate ligands. Notch signaling has anessential role in vascular development and angiogenesis. Recent studies have reported thatNotch may be implicated in Alzheimer’s disease (AD) pathophysiology. We measured thelevels of soluble Notch1 (sNotch1) in the plasma samples from 72 dementia patients (averageage 75.1 y), 89 subjects with amnestic mild cognitive impairment (MCI) (average age73.72 y), and 150 cognitively normal controls (average age 72.34 y). Plasma levels ofsNotch1 were 25.27% lower in dementia patients as compared to healthy control subjects.However, the level of Notch1 protein was significantly increased in human brain microvascularendothelial cells (HBMECs) after amyloid-beta treatment. Also, Notch1 mRNA level wassignificantly increased in HBMECs and iPSC-derived neuronal cells from AD patient comparedto normal control. These results indicate that altered expression of Notch1 might beassociated with the risk of Alzheimer’s disease.

• DOI: https://doi.org/10.1371/journal.pone.0224941
• ISBN or ISSN: 1932-6203

• 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
• This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.