PLoS One, 2019. 14(9), e0222533-, DOI: https://doi.org/10.1371/journal.pone.0222533

Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia

Arang Rhie, Ho-Young Son;Soo Jung Kwak;Seungbok Lee;Dong Young Kim;Bark-Lynn Lew;Woo-Young Sim;Jeong-Sun

Abstract

Dutasteride, a dual inhibitor of both type I and II 5α-reductases, is used to treat male patternhair loss (MPHL). However, patient response to dutasteride varies in each individual, thecause of which is yet to be identified. To identify genetic variants associated with responseto dutasteride treatment for MPHL, a total of 42 men with moderate MPHL who had beentreated with dutasteride for 6 months were genotyped and analysed by quantitative linearregression, case-control association tests, and Fisher’s exact test. The synonymous singlenucleotide polymorphism (SNP) rs72623193 in DHRS9 was most significantly associatedwith response to dutasteride, followed by the non-synonymous SNP rs2241057 in CYP26B1.Additionally, variants in ESR1, SRD5A1, CYP19A1, and RXRG are suggested to be associatedwith response to dutasteride. Cumulative effect and interaction among these SNPswere presented in both additive and non-additive models.

• DOI: https://doi.org/10.1371/journal.pone.0222533
• ISBN or ISSN: 1932-6203

• 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
• This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.