PLoS One, 2019. 14(6), e0217525-, DOI: https://doi.org/10.1371/journal.pone.0217525

Association between body mass index and 1-year outcome after acute myocardial infarction

Dae-Won Kim, Sung-Ho Her; Ha Wook Park; Mahn-Won Park; Kiyuk Chang; Wook Sung Chung; Ki Bae Seung; Tae Hoon Ahn; Myung Ho Jeong; Seung-Woon Rha; Hyo-Soo Kim; Hyeon Cheol Gwon; In Whan Seong; Kyung Kuk Hwang; Shung Chull Chae; Kwon-Bae Kim; Young Jo Kim; Kwang Soo Cha; Seok Kyu Oh; Jei Keon Chae

Abstract

Objectives: Beneficial effects of overweight and obesity on mortality after acute myocardial infarction(AMI) have been described as “Body Mass Index (BMI) paradox”. However, the effects ofBMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomesafter AMI.

Methods: Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015,10,568 patients who eligible for this study were classified into 3 groups according to BMI(Group 1; < 22 kg/m2, 22 ≤Group 2 < 26 kg/m2, Group 3; ≥26 kg/m2). The primary endpoint was all cause death at 1 year.

Results: Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazardratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially,cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI]1.128 to 2.124, p = 0.007).

• DOI: https://doi.org/10.1371/journal.pone.0217525
• ISBN or ISSN: 1932-6203

• 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
• This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.