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Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men
  • 작성일2020-05-07
  • 최종수정일2020-05-07
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 639

BMC Geriatrics, 2019. 19(1), 102-, DOI: https://doi.org/10.1186/s12877-019-1118-y


Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men and women: the Korean Urban Rural Elderly cohort study

Su Jin Lee, Eun Young Lee; Jung Hyun Lee; Jong Eun Kim; Kwang Joon Kim; Yumie Rhee; Hyeon Chang Kim; Yoosik Youm; Chang Oh Kim


Abstract

    Background: Many studies have investigated the association between vitamin D and metabolic syndrome (MetS).However, few studies have investigated the association stratified by sex in the elderly. Therefore, we aimed toevaluate the association between vitamin D, MetS, and its components in Korean elderly men and women.Methods: A total of 987 men and 1949 women aged ≥65 years were recruited through Korean Urban Rural Elderlycohort study. Serum 25-hydroxyvitamin D (25(OH)D) levels were categorized into 4 quartiles and all data wereanalyzed separately by sex. MetS was defined by the revised criteria of the National Cholesterol Education ProgramAdult Treatment Panel III.Results: The participants in the lowest quartile of serum 25(OH)D showed a significant increase in the prevalenceof high waist circumference, elevated triglyceride level, and low high-density lipoprotein cholesterol level, as well asMetS itself, in both men and women in a univariate analysis. After adjusting for potential confounders includingage, smoking status, drinking status, exercise status, region of residence, seasonality, and parathyroid hormone level,the lowest 25(OH)D quartile group was associated with a higher risk of MetS (odds ratio [OR] 2.25, 95% confidenceinterval [CI] 1.48–3.43 in men and OR 1.65, 95% CI 1.27–2.16 in women) compared to the highest 25(OH)D quartilegroup as the reference group. However, no significant association was found between serum 25(OH)D levels andthe prevalence of MetS components including hyperglycemia or hypertension in both men and women.Conclusions: Low 25(OH)D levels were associated with increased odds of MetS; in particular, they were associatedwith MetS components of high waist circumference, hypertriglyceridemia, and low high-density lipoproteincholesterol,after adjusting for age, smoking, alcohol, exercise, region of residency, and seasonality, in men andwomen over 65 years old.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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