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Geriatrics and Gerontology international, 2019. 19(5), 392-398, DOI: https://doi.org/10.1111/ggi.13630
Clinical outcomes of kidney transplantation in older end‐stage renal disease patients: A nationwide cohort study
Eun Jeong Ko, Jaeseok Yang;Curie Ahn;Myoung Soo Kim;Duck Jong Han;Sung Joo Kim;Chul Woo Yang;Byung Ha Chung;Korean Organ Transplantation Registry Group
The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients.
We compared the incidence of biopsy‐proven acute rejection, death‐censored allograft survival and all‐cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients.
A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age ＞60 years (n = 356), and recipients aged＜ 60 years were defined as young recipients (n = 4610). The incidence of biopsy‐proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death‐censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group.
In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality.
- DOI: https://doi.org/10.1111/ggi.13630
- ISBN or ISSN: 1444-1586
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.