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Coronary Artery Disease, 2019. 30(2), 95-102, DOI: https://doi.org/10.1097/MCA.0000000000000684
Immediate multivessel intervention versus culprit-vessel intervention only in patients with ST-elevation myocardial infarction and multivessel coronary disease: data from the prospective KAMIR-NIH registry
Sung Gyun Ahn, Jun-Won Lee;Dae Ryong Kang;Hye Sim Kim;Tae-Hwa Go;Min Heui Yu;Ju Han Kim;Myung Ho Jung;Jong-Seon Park;Shung Chull Chae;Myeng-Chan Cho;Chong Jin Kim;Hyeon-Cheol Gwon;Hyo-Soo Kim;Ki Bae Seung;Kwang Soo Cha;Jei KeonChae;Seung Jae Joo;Seung Woon Rha;Dong-Ju Choi;Seung Ho Hur;In Whan Seong;Doo Il Kim;Seok Kyu Oh;Tae Hoon Ahn;Jin Yong Hwang;Junghan Yoon;on behalf of the KAMIR-NIH registry investigators
BACKGROUND: The safety and efficacy of immediate multivessel coronary intervention (MVI) remain controversial in patients with ST-elevation myocardial infarction (STEMI) and multivessel disease (MVD). This study aimed to investigate the clinical outcomes of immediate MVI compared with culprit-vessel intervention only (CVI-O) in diverse subgroups with STEMI and MVD.
PATIENTS AND METHODS: We compared immediate MVI (n=260) and CVI-O (n=931) regarding 1-year major adverse cardiac event rates for cardiac death, recurrent myocardial infarction (MI), and repeat revascularization in 1191 STEMI patients with MVD using data from the Korea Acute Myocardial Infarction-National Institutes of Health registry (2011-2015). High-risk patients and those who underwent a staged procedure were excluded from the analysis. Furthermore, propensity score matching and stratified subgroup analyses were performed.
RESULTS: Immediate MVI and CVI-O groups had similar 1-year major adverse cardiac event rates [7.7 vs. 8.9%, hazard ratio (HR): 0.86, 95% confidence interval (CI): 0.50-1.47, log-rank P=0.5628]. No difference was found between the groups in terms of the 1-year rate of cardiac death (2.9 vs. 1.3%, HR: 2.24, 95% CI: 0.75-6.67) or recurrent MI (2 vs. 1.5%, HR: 1.41, 95% CI: 0.45-4.44). However, repeat revascularization occurred less frequently in the immediate MVI group than in the CVI-O group (2.0 vs. 5.7%, HR: 0.35, 95% CI: 0.13-0.90, log-rank P=0.0142). These findings were found to be consistent across a broad spectrum of subgroups.
CONCLUSION: Compared with CVI-O, immediate MVI did not improve 1-year net clinical outcomes in stable STEMI patients with MVD. The only benefit found was a reduced repeat revascularization in immediate MVI.
- DOI: https://doi.org/10.1097/MCA.0000000000000684
- ISBN or ISSN: 0954-6928
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.