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Neurobiology of Aging, 2019. n, 1-10, DOI: https://doi.org/10.1016/j.neurobiolaging.2019.10.011
Differences in Neuroimaging Features of Early- versus Late-onset Nonfluent/Agrammatic Primary Progressive Aphasia
Jin San Lee, Sole Yoo; Seongbeom Park; Hee Jin Kim; Key-Chung Park; Joon-Kyung Seong; Mee Kyung Suh; Juyoun Lee; Hyemin Jang; Ko Woon Kim; Yeshin Kim; Soo Hyun Cho; Seung Joo Kim; Jun Pyo Kim; Young Hee Jung; Eun-Joo Kim; nYeon-Lim Suh; Samuel N. Lockhart; WilliamW. Seeley; Duk L. Na; SangWon Seo
This study investigated distinct neuroimaging features measured by cortical thickness and subcortical structural shape abnormality in early-onset (EO, onset age <65 years) and late-onset (LO, onset age ≥65 years) nonfluent/agrammatic variant of primary progressive aphasia (nfvPPA) patients. Cortical thickness and subcortical structural shape analyses were performed using a surface-based method from 38 patients with nfvPPA and 76 cognitively normal individuals. To minimize the effects of physiological aging, we used W-scores in comparisons between the groups. The EO-nfvPPA group exhibited more extensive cortical thickness reductions predominantly in the left perisylvian, lateral and medial prefrontal, temporal, posterior cingulate, and precuneus regions than the LO-nfvPPA group. The EO-nfvPPA group also exhibited significantly greater subcortical structural shape abnormality than the LO-nfvPPA group, mainly in the left striatum, hippocampus, and amygdala. Our findings suggested that there were differences in neuroimaging features between these groups by the age of symptom onset, which might be explained by underlying heterogeneous neuropathological differences or the age-related brain reserve hypothesis.
- DOI: https://doi.org/10.1016/j.neurobiolaging.2019.10.011
- ISBN or ISSN: 0197-4580
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.