Gene, 2019. 703, 58-64, DOI: https://doi.org/10.1016/j.gene.2019.04.013

Glucose transporter 3 gene variant is associated with survival outcome of patients with non-small cell lung cancer after surgical resection

Sook Kyung Do, Lee SY;Choi JE;Hong MJ;Kang HG;Lee WK;Lee EB;Shin KM;Jeong JY;Lee YH;Seo H;Yoo SS;Lee J;Cha SI;Kim CH;Seok Y;Cho S;Jheon S;Park JY;Choi SH

Abstract

This study was conducted to explore whether polymorphisms of glucose transporter 3 (GLUT3) gene affect theprognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Four single nucleotidepolymorphisms (SNPs) in GLUT3 were investigated in a total of 782 patients with NSCLC who underwentcurative surgery. The association of the SNPs with overall survival (OS) and disease free survival (DFS) wasanalyzed. Among the four SNPs investigated, GLUT3 rs7309332C>T was significantly associated with OS andDFS in multivariate analyses. The SNP was associated with significantly worse OS (adjusted hazard ratio[aHR]=1.62, 95% confidence interval [CI]=1.04–2.53, P=0.03, under recessive model), and worse DFS(aHR=1.64, 95% CI=1.18–2.29, P=0.003, under recessive model). When stratified by tumor histology, theassociation between the GLUT3 rs7309332C>T and OS/DFS was not limited to either squamous cell carcinoma(SCC) or adenocarcinoma (AC), although the significant association remained only in AC for OS (P=0.40 forSCC and P=0.04 for OS) and only in SCC for DFS (P=0.03 for SCC and P=0.08 for OS). When AC patientswere stratified according to EGFR mutation status, the SNP was significantly associated with DFS in patients withEGFR mutant tumors (aHR=2.47, 95% CI=1.15–5.30, P=0.02, under recessive model), but not in those withEGFR wild-type tumors. This study suggests that genetic variation in GLUT3 may be useful in predicting survivalof patients with early stage NSCLC.

• DOI: https://doi.org/10.1016/j.gene.2019.04.013
• ISBN or ISSN: 0378-1119

• 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
• This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.