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연구성과(결과보고서,논문,특허)
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Comparison of neonatal outcomes of very low birth weight infants by mode of conception...
- 작성일2020-02-04
- 최종수정일2020-02-10
- 담당부서연구기획과
- 연락처043-719-8033
- 976
EPIDEMIOLOGY, 2019. 111(5), 962-970, DOI: https://doi.org/10.1016/j.fertnstert.2019.01.014
Comparison of neonatal outcomes of very low birth weight infants by mode of conception: in vitro fertilization versus natural pregnancy
Ju Sun Heo, Hee Jun Lee; Myung hee Lee; Chang Won Choi
Abstract
- Objective
To compare the neonatal outcomes of very low birth weight (VLBW) infants born after IVF with those of VLBW infants born after natural pregnancy (NP).
- Design
Prospective cohort study.
- Setting
Not applicable.
- Patient(s)
A total of 6,871 VLBW infants born from January 2014 to December 2016.
- Intervention(s)
None.
- Main Outcome Measure(s)
Neonatal mortality and morbidities.
- Result(s)
Of the 6,871 VLBW infants enrolled, 4,438 infants were born as singletons (IVF = 271; NP = 4,167), and 2,433 infants were born as multiplets (IVF = 1,301; NP = 1,132). After adjustment for maternal and neonatal baseline characteristics, infants born as singletons earlier than 28 weeks after IVF more frequently had high-stage retinopathy of prematurity than those born after NP, whereas infants born as multiplets between 28 and 31 weeks after IVF had fewer major congenital anomalies, high-grade intraventricular hemorrhage, and periventricular leukomalacia than those born after NP. Otherwise, no differences in mortality and neonatal outcomes were found.
- Conclusion(s)
Very low birth weight infants born as singletons after IVF had comparable neonatal outcomes to those born after NP, except for an increased risk of high-stage retinopathy of prematurity. Very low birth weight infants born as multiplets after IVF had fewer neurologic morbidities than those born after NP.
- DOI: https://doi.org/10.1016/j.fertnstert.2019.01.014
- ISBN or ISSN: 1044-3983
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.
