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Alcohol, 2019. 79, 137-145, DOI: https://doi.org/10.1016/j.alcohol.2019.03.004
The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea
Yoo Jeong Lee, Min-Gyu Woo; Hyeon-Kyeong Kim; Han Byul Jang; Keon Jae Park; Hye-Ja Lee; Sung-Gon Kim; Sang Ick Park
• Alcohol-metabolizing enzymes are influenced by ethnic variability and genetics.
• Variations in SRPRB and PGM1 were associated with lower blood alcohol concentrations in subjects.
• A variation in ADH1A was associated with higher blood acetaldehyde concentrations in subjects.
Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and a wide range of negative health consequences, from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics.
In this study, subjects were administered a single dose of alcohol (0.6 g/kg for men or 0.4 g/kg for women), and blood alcohol and acetaldehyde concentrations were measured eight times over 5 hours. To investigate genetically susceptible factors to alcohol metabolism, we selected single-nucleotide polymorphisms (SNP) of genes identified by prior genetic association studies for alcohol metabolism, alcohol consumption, alcohol dependence, and related traits, and performed genotyping on all subjects (n = 104).
We identified variations in the ADH1A, SRPRB, and PGM1 genes, which are directly associated with blood alcohol or acetaldehyde concentrations. Namely, the T allele of SRPRB rs17376019 and the C allele of PGM1 rs4643 were associated with lower blood alcohol levels, while the ADH1 rs1229976 C allele group exhibited markedly higher blood acetaldehyde levels than those of the ADH1 rs1229976 T allele group.
This study demonstrates that genetic variations in ADH1A, SRPRB, and PGM1 are associated with variations in blood alcohol and acetaldehyde concentration after alcohol intake.
- DOI: https://doi.org/10.1016/j.alcohol.2019.03.004
- ISBN or ISSN: 0741-8329
- 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
- This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.