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Application of an amyloid and tau classification system in subcortical vascular cognitive ...
  • 작성일2020-02-04
  • 최종수정일2020-02-10
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 877

European Journal of Nuclear Medicine and Molecular Imaging, 2019. n, 1-12, DOI: https://doi.org/10.1007/s00259-019-04498-y


Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients

Hyemin Jang, Hee Jin Kim; Seongbeom Park; Yu Hyun Park; Yeongsim Choe; Hanna Cho; Chul Hyoung Lyoo; Uicheul Yoon; Jin San Lee; Yeshin Kim; Seung Joo Kim; Jun Pyo Kim; Young Hee Jung; Young Hoon Ryu; Jae Yong Choi; Seung Hwan Moon; Joon-Kyung Seong; Charles DeCarli; Michael W. Weiner; Samuel N. Lockhart; Soo Hyun Cho; Duk L. Na


Abstract

Objective
To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer’s disease (AD), and to investigate its clinical significance.

Methods
We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A−/A+) and tau (T−/T+) based on PET results. Across the three SVCI groups (A−, A+T−, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models.

Results
Among SVCI patients, 33 (55%), 20 (33.3%), and seven (11.7%) patients were A−, A+T−, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9%) than in A+ADCI (14/20, 70.0%, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T−SVCI had steeper cognitive decline than A−SVCI. A+T+SVCI also showed steeper cognitive decline than A+T−SVCI. Also, A+T−SVCI had steeper decrease in HV than A−SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T−SVCI, while declines in HV did not differ between the two groups.

Conclusion
This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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