본문으로 바로가기 주메뉴 바로가기

사용자별 맞춤메뉴

자주찾는 메뉴

추가하기
닫기

연구성과

contents area

detail content area

Elevated Red Blood Cell Distribution Width Is Associated with Morphometric Vertebral Fracture...
  • 작성일2020-02-04
  • 최종수정일2020-02-04
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 980

Calcified Tissue International, 2019. 104(1), 26-33, DOI: https://doi.org/10.1007/s00223-018-0470-9


Elevated Red Blood Cell Distribution Width Is Associated with Morphometric Vertebral Fracture in Community-Dwelling Older Adults, Independent of Anemia, Inflammation, and Nutritional Status: The Korean Urban Rural Elderly (KURE) Study

Namki Hong, Chang Oh Kim;Yoosik Youm;Jin‑Young Choi;Hyeon Chang Kim;Yumie Rhee


Abstract

    Elevated red blood cell distribution width (RDW), a simple measure of red blood cell size heterogeneity, has been associatedwith increased mortality and morbidity in the elderly population, which might reflect systemic inflammation and malnutrition.However, whether elevated RDW is associated with prevalent morphometric vertebral fracture (VF) in older adults hasnot been investigated. We examined 2127 individuals (mean age 71.7 years; women 66%) from a community-based cohort.VF was defined as ≥ 25% reduction in vertebral column height using the Genant semiquantitative method. Multiple VF wasdefined as the presence of VF at two or more sites. The prevalence of any VF and multiple VF was 14% and 4%, respectively,increasing from the lowest to the highest RDW tertiles (12–18% and 3–6%, p for trend < 0.05 for all). RDW was positivelyassociated with age, body mass index (BMI), malnutrition, and high-sensitivity C-reactive protein (hsCRP), whereas it wasnegatively associated with albumin, hemoglobin, and ferritin levels. Elevated RDW was associated with any VF [adjustedodds ratio (aOR) 1.26; p = 0.008] and multiple VF (aOR 1.36; p = 0.010) after adjustment for covariates, including age, sex,BMI, hsCRP, malnutrition, self-reported previous fracture, falls, osteoporosis, and hemoglobin and ferritin levels. The associationbetween elevated RDW and VF remained robust in subgroups with (aOR 1.39; p = 0.048) or without anemia (aOR1.26; p = 0.030). Elevated RDW was associated with prevalent morphometric VF in community-dwelling elderly individuals,independent of anemia, inflammation, and nutritional status.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


본 공공저작물은 공공누리  출처표시 조건에 따라 이용할 수 있습니다 본 공공저작물은 공공누리 "출처표시" 조건에 따라 이용할 수 있습니다.
TOP